English name: MTX; Methotrexate; (+) -Amethopterin; (+) -4-Amino-10-methylfolic acid; N- (p- (((24-Diamino-6-pteridinyl) methyl) methylamino) benzoyl) -L -glutamic acid
Other names: methotrexate; methylamino folic acid; methotrexate; on - [(2,4-eranjidieding-6) -N-jiajijiaanji] benzoyl glutamate; dihydrate methotrexate purine; (+) ammonia methotrexate; N- [4 - [[(2,4-eranji-6-dieding) jiaji] methylamino] benzoyl] -L- glutamic acid
C20H22N8O5 = 454.44
Level: ACS Grade
Product Description: Antineoplastic agent that acts as an antimetabolite of folic acid biosynthesis Inhibits the enzyme dihydrofolate reductase and prevents formation of tetrahydrofolate..
Traits: orange yellow crystalline powder Melting point 185-204 ℃ soluble in dilute alkali carbonate solution or an alkali metal, slightly soluble in dilute hydrochloric acid, almost insoluble in water, ethanol, chloroform, ethyl ether.
Use: Biochemical studies of folic acid agonists must rely on blocking the synthesis of thymidine tetrahydrofolate cofactors to block DNA synthesis by methotrexate folic acid transporter in the cells into the cell, which is an acid leaves together.... glutamate synthetase (folylpolyglutamate synthase) is converted to a high molecular weight poly-glutamic acid metabolites, and binding to dihydrofolate reductase (dihydrofolate reductase), thereby inhibiting its activity of methotrexate - polyglutamic acid is γ - glutamyl hydrolase (γ-glutamyl hydrolasen) intracellular degradation.
Save: -20 ℃
Dangerous nature: Class 6.1 toxic chemicals