English name: Ara-C; Cytosine β-D-arabinofuranoside; Cytosine arabinoside; 4-Amino-1-beta-D-arabinofuranosyl-2 (1H) -pyrimidinone; Arabinocytidine
Other names: cytosine-β-d-arabinoside furan; 1-amino-β-d-furanose base-2 (1H)-pyrimidinone; Arabinose cytosine; Cytosine arabinoside; Arabinofuranose base cytosine; Arabinose base cytosine
CAS number: 147-94-4
Level: Ultra Pure Grade
Content: ≥ 98.0% (HPLC)
Specific rotation: 156~161 °
Appearance: white or white crystalline powder, soluble in water, ethanol, chloroform, partly soluble in methanol, and practically insoluble in ether, melting point 186~188℃
Use: biochemical studies. Inhibits DNA polymerase that interferes with nucleotide into DNA and inhibit nucleotide reductase, blocking the restore deaeration CMP CMP, but on RNA and protein synthesis with no significant effect. Ara-C inserted DNA, and topoisomerase I (topoisomerase I) formed complexes inhibit DNA replication, resulting in DNA cleavage. No inhibition of RNA synthesis.