Paeoniflorin

Paeoniflorin
 

Product description:

Paeoniflorin
(Product name) Paeoniflorin
(English name) Paeoniflorin
(Formula) C23H28O11
(Molecular weight) 480.45
(CASNO) 23180-57-6
(Purity) 98% 90% 50% 45% 40% 20% 10%
(Vegetable source) Ranunculaceae plant peony root, peony root, purple peony root
(Physical Properties) an amorphous tan powder (90% of white powder) Melting point: 196 ℃ in the acidic environment of paeoniflorin stability (pH2 ~ 6), is unstable in an alkaline environment.
(Pharmacological effects) Paeoniflorin dilation of blood vessels, sedation, anti-inflammatory anti-ulcer, antipyretic and antispasmodic, diuretic effect.
1. The anti-inflammatory and analgesic effects of pharmacological studies powder total glucosides of peony (TGP) showed, TGP powder 50 ~ 150mg? Kg-1? D-1 (ip) significantly inhibited rat carrageenan-induced formed foot swelling and rat granuloma, and adjuvant arthritis have significant preventive and therapeutic effect; 100 ~ 300 mg kg-1 d-1 (ip) significantly inhibited mouse ear two?? toluene-induced inflammation, indicating that the drug for acute, chronic and autoimmune inflammation are inhibited;? TGP powder 100-300 mg kg-1 d-1 can significantly reduce the mouse acetic acid-induced writhing? revealed the drug has analgesic effects. In short, the experiment showed that TGP powder has a certain anti-inflammatory and analgesic effects.
2. Adjust the immunity pharmacology studies showed that injection of TGP, TGP can inhibit the immune response appropriate dose of specific cells and monocytes / macrophages, T lymphocytes function, no significant effect on the immune organ weight. For TGP small murine systemic lupus erythematosus (SLE) like change of the protective effect of experiments show, TGP levels of autoantibodies, lymphocyte proliferation showed inhibition antagonized elevated levels of IL-l, a dose TGP SLE in mice have immune recovery action. worthy of further exploration prospects may immunomodulatory mechanisms and treatment of SLE TGP's. Studies have shown that Chuanwu and peony compatibility on cellular immunity has obvious two-way adjustment, can significantly inhibit the normal and elevated immune mice delayed type hypersensitivity (DTH), significantly inhibited rat adjuvant arthritis secondary, but also significantly improve the immunocompromised mouse monocyte macrophage phagocytosis. In contrast, each single herb regulatory role relatively weak. Therefore, immune disorders may be one of the important mechanisms black peony compatibility treatment of rheumatoid Arthralgia clinical application. TGP has as the first anti-inflammatory immunomodulatory drugs are officially approved for production market, for inflammatory autoimmune diseases treatment play a major role.
3. The anti-aging effects studies show that water peony root decoction can significantly enhance the activity of SOD in aged mice, whole blood GSH-Px vitality, significantly lower plasma levels of red blood cells and MDA suggesting its aging-related enzyme by increasing RBC -S0D activity and GSH-Px activity and decrease aging catabolite -MDA content, remove the damage caused by free radicals, to avoid excessive lipid oxidation damage cell structure and function, red blood cells and plasma enhanced oxidation resistance, protection of red blood cells, thereby delaying cell aging and protect the structure and function of the cell membrane, it has anti-aging effect.
Packing: 1kg / aluminum foil bag, 25kg / drum (double plastic bags sealed cardboard Outsourcing)
Storage conditions: Store in cool, dry, dark, avoid high temperature
Duration: 24 months
Note: kaempferol should be sealed from light, prolonged exposure to air, the content will be reduced.