Tamoxifen Citrate (Nolvadex, 54965-24-1)
Chemical Name: (Z) -2-[4-(1, 2-Diphenyl-1-butenyl)phenoxyl]-N, N-dimethyl-ethanamine-citrate;
Synonyms: Farmifeno; Oncomox; Tafoxen; Kessar; Tamoxasta; Soltamox; Noxitem; Oncotam
Molecular Formula: C26H29NO. C6H8O7
Molecular weight: 563.64
Appearance: White crystalline powder
Standard: Enterprise Standard
Melting Point: 140-144 ° C
Boiling Point: 665.9 ° C at 760 mmHg
Flash Point: 356.5 ° C
Solubility: Slightly soluble in water
Usage: A nonsteroidal antiestrogen. Used for treatemnt of advanced, metastatic breast cancer.
Storage: In dark and cold place
tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamexifen. in other tissue such as the endometrium, tamoxifen behaves as an agonist. Hence tamoxifen maybe be characterized as a mixed agonist, tamoxifen has been the standard endocrine therapy for hormone receptor-postive early breast cancer in pre-menopausal women, although aromatase inhibitors has been proposed. tamoxifen was discovered by ICI pharmaceuticals.
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