Synonyms: cinnamon potassium, cinnamic acid and potassium
English name: Potassium cinnamate
CAS Number: 16089-48-8
Molecular Weight: 186.25
Melting point: 34 ~ 36 ℃
Properties: white crystalline powder, soluble in water, slightly soluble in ethanol, microstrip cinnamon flavor.
The main purpose
Cinnamon is a non-toxic potassium slightly with cinnamon flavor, easy to dissolve water antiseptic and anti-oxidants, it will replace the traditional preservative; and has anti-fatigue, promote metabolism, anti-inflammatory, anti-cancer, dilation of blood vessels, keeping excitement and blood pressure and other health functions, also used as a food spice formulations can be directly added to food, but also can be used as the main ingredient made functional beverages and health food.
Cinnamon potassium has the following characteristics:
1.1 broad spectrum
Antibacterial ability, especially for food spoilage caused by mold, bacteria and yeast action is very strong, its inhibitory effective concentration of mold 0.05-0.1%, commonly used amount of 0.01-0.02%, inhibiting effective concentration of bacteria 0.01 -0.1% mainly inhibit object also includes the genus Pseudomonas streptozotocin, Micrococcus, Bacillus, Enterobacteriaceae, Vibrio, halophilic Bacillus, addicted to gas bacteria, milk dry species, lactic acid bacteria, Aflatoxin, Escherichia coli, Proteus vulgaris, Lactobacillus casei, butyric acid bacteria, Lactobacillus plantarum, aerobic bacillus, Gram positive and negative bacteria, Clostridium botulinum, etc. Meanwhile, cinnamon potassium unrestricted pH , PH value between 2-7 inhibitory effect is quite good, and the inhibitory effect is not due to fluctuations in PH changes, it can be widely used in various foods.
1.2 Safety practicality
Cinnamon potassium oral LD50 rat 5.58-6.78g / kg; cinnamon products are non-toxic potassium after absorption into the body by the metabolism of phenylalanine excreted small amounts of phenylalanine may be phenylalanine. catalytic generation tyrosine hydroxylase, the human body without any toxicity of its effective preservatives cinnamic acid in 1965 FEMA (flavoring extracts Manufacturers Association) identified it as GRAS (which is usually considered to be safe ).
Effective antiseptic ingredient cinnamon potassium or one of a variety of cell differentiation of natural differentiation-inducing agent that has anti-fatigue, promote metabolism, anti-inflammatory, anti-cancer, dilation of blood vessels, keeping the excitement and blood pressure and other health functions.
2. cinnamon antiseptic properties of potassium
Natural cinnamon extract cinnamic acid potassium salt, potassium cinnamon system, because of its good solubility is widely used in food, which is cinnamon potassium corrosion mechanism under acidic conditions converted into cinnamic acid. Cinnamic acid pKa at 4.37-4.44 weak acid, most of which rely on the antimicrobial effect in the form of undissociated acid molecules. weakly ionized into ions incomplete when dissolved in water, but formed a balance between the charged, ionized form and the uncharged, undissociated form. Both forms of proportional dependence of the solution pH. acidic solution, the stronger, the more undissociated form. Since the fifties, has learned cinnamic acid antimicrobial action is through inhibition of phenylalanine and tyrosine microbes in its undissociated form, cinnamic acid as a weak acid preservative is considered to be soluble in a microorganism membrane into the cell, the ionization at higher pH environment and thus lower the internal pH;. can effectively affect many important enzymes activity, thus eventually kill the contaminating cells.
3 cinnamon potassium health and pharmacological studies
Cinnamon has anti-tumor effect of potassium, anti-mutagenic activity in vitro, can inhibit the carcinogenic agent in rodents induced by a variety of tumors. Recent studies have found that the active ingredient of cinnamic acid potassium cinnamon can inhibit glioblastoma, melanoma the proliferation of tumors and hormone-insensitive prostate cancer cell lines, human lung cancer cells of highly metastatic malignant phenotype and inhibit the invasion role reversal, can induce human lung adenocarcinoma cells, human hepatoma cells, human promyelocytic leukemia cells, etc. differentiation, is a variety of cell differentiation of natural differentiation-inducing agent; cinnamic acid is A-5491 human lung adenocarcinoma cell potent inhibitor, has great potential applications in fighting cancer, can increase blood leukocytes content, anti-radiation, as well as anti-tumor, lung tumor, tuberculosis role.
3.2 hypoglycemic and lipid
Kang-Beom Kwon et of streptozotocin (STZ) diabetic mice were given cinnamon potassium, high, medium and low-dose continuous 7d, had no effect on blood sugar levels normal control mice, treated mice had significantly hypoglycemic effect, high, medium and low dose group showed a decline in blood sugar levels followed by dose-effect relationship of plasma insulin levels also increased significantly (compared with control group P (0.01), dose-effect relationship. Diabetes is a common endocrine and metabolic disease, often accompanied by lipid metabolism and hyperlipidemia. Long-term high blood sugar, high cholesterol easily induced diabetic cardiovascular disease. In the treatment of diabetes, lower blood sugar and blood fat is almost as important as a number of experimental results It showed that cinnamon in lowering blood sugar, potassium while lowering blood lipids, suggesting cinnamon potassium to control diabetes and its complications have a certain role.
3.3 Antimicrobial resistance to fatigue
Cinnamon can be added directly or potassium complex manufacturing fungicides, hemostatic, and has anti-fatigue effect; with good antibacterial and kill Trichomonas effect, for wound healing have a certain effect, can be used like a Band-Aid external medication; there is sleep and adequate blood supply to the heart in order to achieve the effect of nourishing the heart shelter; anti-platelet aggregation; promote metabolism, anti-enteritis, has anti-inflammatory effect; can be directly used as a stimulant, it has a good effect.
Potassium is itself a cinnamon spice, aroma and has a good effect, usually with incense as a raw material, the main spice aroma can be more volatile fragrance. Various esters of cinnamic acid (such as A, B, C, D, etc.) can be used as a fixative agent for drinks, cold drinks, candy, wine and other foods. cinnamic acid, also known as β-phenyl-n-propyl acrylate, n-propyl, with a special peach and apricot, wine-like flavor, widely used Food, tobacco, cosmetics, soaps perfumery agent is a perfume to be developed at the same time also as potassium cinnamon apple flavors, cherry flavors, fruit flavors, floral fragrance harmonic use; can be used as an aromatic mixture used in soap , shampoo, detergent, cosmetics In the cosmetic applications, inhibit the formation of black tyrosinase effect on the UV cut off a certain role, make lighter brown spots, or even disappear, is a senior sunscreen the indispensable raw materials.
1, silver, palladium mixed, nitric acid, dropping after warming in the filtrate by silver, palladium, carbon molar ratio of added carbon, adjusted with KOH solution pH, have cake for the silver oxide, palladium hydroxide and Toner mixture;
2, according to the mixture, KOH aqueous solution of silver oxide, palladium hydroxide and carbon powder mixture was added an aqueous solution of KOH, cooling, dropwise addition of aqueous formaldehyde solution, the reaction after the dropwise addition, the material was filtered, washed with water until neutral, and drying;
3, potassium hydroxide solution was added to a silver / palladium / carbon catalyst, stirring until mixed material; heating the material, which leads to pure oxygen, regulate the temperature of materials to give cinnamon aqueous potassium;
4, cinnamon aqueous potassium filtration, the resulting cake is a silver / palladium / carbon catalyst, cooling, crystallization, centrifugal drying, vacuum drying cinnamon potassium finished method is simple, low cost, high yield, on the environment non-polluting, suitable for industrial production. Yield up to 95.9%.