P-hydroxy cinnamic acid
Alias: 4-hydroxy cinnamic acid, coumaric acid, 3- (4-hydroxyphenyl) acrylic acid
English name: 4-hydroxylcinnamic acid
CAS Number: 501-98-4 / 7400-08-0
Molecular formula: C9H8O3
Molecular Weight: 164.20
Melting point (℃): 210 ~ 213
Loss on drying: ≤1.0%
Residue on ignition: ≤0.5%
Product content: ≥98%
. Properties: white or light yellow powder was dissolved in hot ether; hot ethanol; slightly soluble in benzene; insoluble in petroleum ether.
Packing: 25kg / drum
Customs Code (HS): 2916399090, rebate of 9% The main purpose
1, p-hydroxy cinnamic acid application in medicine
Pharmaceutical intermediates;. Expectorants cuckoo pigment intermediates in the pharmaceutical industry for the production of coronary heart disease treatment satisfying given intermediate, as well as for the manufacture of topical anesthetic, sterilization, and hemostatic agents and the like. 2, p-hydroxy cinnamic acid in agriculture
The main raw material ethylene stuffed pesticide industry for the production of oil in plant growth promoter, long-lasting anti-fungicides and fresh fruits and vegetables with the agent. In addition, cinnamic acid is also used as a measurement of uranium and hunger chemicals for the production of a photosensitive resin hanging IV. cinnamic acid compound is not only a number of spices. 3, p-hydroxy cinnamic acid in the chemical industry
(1) p-hydroxy cinnamic acid is very important flavors and fragrances, allows the use of food flavors, mainly used for the preparation of spicy cherry, apricot, honey and spices until in the cosmetic industry for preparation of soap and cosmetics flavor.
(2) p-hydroxy cinnamic acid is a potent conductive material, widely used in the liquid crystal display industry in recent years by a hydroxyl group on the graft reaction with polyimide hydroxy cinnamic acid and having photosensitivity of hydroxy poly imide; and determined by IR, NMR photosensitivity of the hydroxyl polyimide structure of synthetic hydroxy polyimide liquid crystal alignment layer used in the liquid crystal display device;. prove its good thermal stability . Preparation Process
1, acetylsalicylic acid chloride as raw materials in the presence of magnesium chloride in an acetonitrile solvent with malonic acid ethyl ester, and then adding triethylamine, the reaction at 0 ℃ 1h, to give (2-acetoxy-benzoyl ) malonate product was then heated to 50 ℃ potassium hydroxide / methanol solution, the reaction 3h, the product obtained is cyclized.
2, with ethyl acetoacetate as raw materials in the presence of sodium hydroxide in methyl isobutyl ketone solvent and acetylsalicylic acid chloride at 15 ~ 20 ℃ 3.5 h, to give 2- (2-hydroxy-benzoyl) acetyl acid sodium salt, reaction product with hydrochloric acid in 25 ~ 30 ℃ 30min, to give 3-acetyl-4-hydroxy-coumarin, and then concentrated sulfuric acid was heated at 90 ~ 95 ℃ 4h to obtain a product.
3, using 2-hydroxyacetophenone as raw materials in the presence of potassium carbonate, in an autoclave 5.88MPa pass into carbon dioxide, through 15h at room temperature, and then kept 15h at 60 ℃, Mr. Cheng 2-hydroxyphenyl -3- oxygen acid, and then ring synthetic products